Wastewater of Moringa Oleifera and Momordica Charantica As the Treatment of a Malignant Carcinoma Patient by Correcting the Number of MC/VER, Lymphocy

1.1.Null Hypothesis

Triterpenoids, triterpene glycosides, phenolic acid, falvonoids, lectins, sterols, and proteins are the variety of phytochemicals that are factorial in the increasement or decreasement of blood types, including lymphocytes and eosinophil which both of them role human’s immune system, cytokines activity, and response that will ultimately influent the number of MC/VER in human body. These phytochemicals are known to be consisted by bitter melon or Momordica Charantica. In many pre-clinical systems, the Momordica charantia extract exhibits an anti-cancer action against various malignancies (Sur, S and Ray. R. B. 2023). Momordica Charantia also indicates anticancer shield through its barriers toward cancer cell and stimulation on apoptosis in different cancer models. On top of cancer inhibition, bitter melon also performs anti-inflammatory, antioxidant, and immunomodulatory effects.

Meanwhile for Moringa Oleifera, the isothiocyanates present in the leaves or leaf extracts have been shown to modulate critical signal transduction pathways involved in cancer (Sodvadiya, M., Patel, H., Mishra, A. et al. 2020). Body fitness and overall health improvision are two of many nutraceutical benefits of the Moringa Oleifera or so-called the drumstick leaf.

Based on two informations, the therapeutic effect is scientifically observed on the substances, hence the wastewater that contains the extract works. From this null hypothesis, I decided to operate the treatment with focused observation toward official follow-up on the number of MC/VER, lymphocytes, and eosinophil, with no limitation to monocytes.

TOOLS

1. PAN (or a teapot) for boiling
2. Mug
3. Stove
4. Spoon and Knife

MATERIALS

1. Bittermelon (1)
2. Drumstick leaf (1gr)
3. Mineral water (350 mL)

Wash the drumstick leaf cleanly and one bitter melon with salt to prevent insects.

FOR DRUMSTICK LEAF:

1. Have a clean sink or bowl as the medium
2. Fill the sink/bowl with water until it reaches half (1/2) of its volume
3. Separate drumstick leaf from the stem (the best you can, a little stem is fine)
4. Put the drumstick leaf inside the filled sink/bowl
5. Pour one (1) tablespoon of salt and mix it with your hand
6. Let it two (2) minutes
7. Rinse the water

FOR BITTER MELON:

1. Have a clean bowl as the medium
2. Fill the sink with water until it reaches quarter (1/4) of its volume
3. Slice the bitter melon into three (3) medium-sized slices.
4. Pour salt into the bowl and put three (3) slices of bitter melon
5. Wash for thirty (30) seconds with your hands
6. Let it for two (2) minutes
7. Rinse the water

FOR DRUMSTICK LEAF:

1. Pour 350 mL of mineral water into pan
2. Turn the stove on medium heat
3. Put the leaf and leave it for fifteen (15) minutes
4. Watch the water's pigment slowly changes into brownish (like a tea) with so 'leafy' aroma.

FOR BITTER MELON:

1. Pour 350 mL of mineral water into pan
2. Turn the stove on medium heat
3. Put three (3) slices and leave it for ten (10) to fifteen (15) minutes until the bitter melon gets softened and the water is murky pigmented.

FOR DRUMSTICK LEAF:

1. Wait until the wastewater warm and have a small sieve
2. Filter the water from the leaf (some leaf may enter the mug, optional)
3. Serve separately from bitter melon for better taste and benefit. Typically served in the morning.

FOR BITTER MELON:

1. Pour the wastewater with three slices of bitter melon into a mug
2. Serve separately from drumstick leaf for better taste and benefit. Typically served in the afternoon or noon.

4.1.Carcinoma

Carcinoma or famously identified as bronchogenic carcinoma is one of the leading death causes of cancer in the U.S. This cancer originally locates in parenchyma or inside the bronchi that has been responsible for higher death rate than breast cancer in 1987.

4.2.MC/VER

Mean Corpuscural Volume or MC/VER is an average volume measurement for Red Blood Cells (RBC) whose rate can be obtained by operating Complete Blood Count or CBC. Red blood cells’ abnormality can occur, normally for an ill person, hence the diagnose is mandatory to identify the abnormality and further step taken into the person.

Tabel 4.1.MC/VER Number

AGE

NORMAL MC/VER NUMBER (fL)

Newborn

98-122 fL

1-3 years old

73-101 fL

4-5 years old

72-88 fL

6-10 years old

69-93 fL

Adult

80-100 fL

1 fL = 0.0000000000000001 liter

MC/VER number varies, but does not rocketing high in number, depend on the hospital policy and the person medical condition.

4.3.Lymphocytes

Lymphocytes are immune system helper to fight cancer, viruses, and bacterias inside your immune system which mostly develop inside your bone marrow. Just like the job description, lymphocytes is a white blood cell type with two main blood cell types, viz T lymphocytes (T cells) for infected and tumor cells and B lymphocytes (B cells) for antibodies. The existence of lymphocytes is notably important for any cancer survivor. Since the procedural work of lymphocytes involves cancer, virus, and bacteria fight. According to Cleveland Clinic, lymphocytes works by shapeshifting into memory cells after remembering the contacted antigen so they recognize the antigen swiftly. The same reason is why we normally never encountered chickenpox twice.

Tabel 4.2.Lymphocytes Number

AGE

AMOUNT (MicroLiter)

Differential Count (%)

Children

3,000 - 9,000 per microliter of blood

Adult

1,000 - 4,800 per microliter of blood

20-40% of your white blood cells

4.4.Eosinophil

White blood cell variation as the immune system component with responsibility to combate multicellular parasite and vertebratae infection that is mostly associated with control mechanism like asthma, allergy, until a certain cancer. Likewise lymphocytes, eosinophil is developed inside bone marrow before migrating into blood. Eosinophil is pinkish. It has 8 to 12 hours of lifespan with correspondence in time of the day.

Tabel 4.3.Eosinophil Range

CATEGORY

COUNT

Mild

500 to 1,000 eosinophils per microliter blood

Moderate

1,000 to 5,000 eosinophils per microliter blood

Severe

more than 5,000 eosinophils per microliter blood

4.5.Monocytes

Monocytes are responsible for dead tissues or damaged one to be removed. Since they are white blood cell category, they do fight infections and active inflammatory process. Monocytes are actually the largest type of leukocyte with ability to differentiate into macrophages, that are mostly found in body tissues, and monocyte-derived dendritic cells. Monocytes is originated form bone marrow from precursors called monoblasts with one to three days bloodstream circulation schedule and representation portion of 4 to 8 percents of total cells.

4.6.Momordica Charantica 

Widely grow in Asia, Africa, and Carribean. Momordica Charantica is an edible bitter-tasted fruit with prominent appearance of its wavy and protruding greenish skin or so-called tendril. This Cucurbitaceae family grows up to twelve centimeters with three to seven separated lobes and bears yellow male and female flowers. The popularized story of high-fibre and nutritious benefit has been proven true, alone with the anti-cancer substance, cathecin, epicathechin, gallic acid, and chologenic acid with antioxidant to protect cells against damage.

4.7.Moringa Oleifera

Drumstick Leaf is a Moringaceae family with cultivation widely spreads across the South and Southeast Asia. The feathery leaf structure and light green fragile stem who can grow up to thirty-nine feet uniquely categorizes drumstick leaf as a Moringa genus and is popularly labeled as an antioxidant and anti-inflammatory property.

5.1.Subject JA

Initial JA, age 54, is an Indonesian factory worker with history of working in chemical factory, generator machine industry, and ultimately a fragile product distributor company. JA possesses history of smoking habit at the age of twelve and remains for forty-two years, along with long-distance motorcycling habit. With temporal conclusion for the cause of carcinoma is smoking, industrial dust, chemical substance, and radiation from active generator machine. 

JA has undergone two years medication at Persahabatan General Hospital with lung specialist, Doctor Jamal, PhD, Sp.P(K) and internal disease, Doctor Maulana S, Sp.PD. 

JA chemotherapy history was mainly from medicine. In early 2023, JA took EL chemotherapy medicine for nearly six months and abruptly stopped due to internal disease complain that included inflammation on body part, nauseous, and excessive cough, along with abnormal number and percentage of blood cell that weakened his immune system. In early 2024, JA takes chemotherapy medicine, brand OT from Indonesian Cancer Foundation for five months before being restricted financially and abdominal complain, including inflammated stomach, eating disorder, and excessive vomiting (all based on personal view).

JA’s experiment journey may be confusing, notably in chemotherapy medicine involvement in the treatment era, so I will simply breakdown the timeline for better understanding (see the attached image)

Between the gap year and July continuity, I experimented Moringa Oleifera and Momordica Charantica wastewater as a side treatment for JA’s blood cells control in order to suffice the health readiness for future chemotherapy infusion. With diagnosed and regular schedule elaborated in the next chapter.

5.2.Progress

MONTHS

Mid-AUG

JA remained complaining about nauseous, inflammation body parts like arms and legs, skin itchy, and numbness on tongue, cough, and cancerous impact like suffocation, weakened body, and crowded lungs sensation (not liquid complain)

Late-AUG

JA began to have his appetite and be more open to vegetable. Nauseous, inflammation, skin itchy, cough, and any cancerous impacts remained.

Early-SEP

JA lost his appetite due to cancerous impact. Nauseous decreased, skin itchy decreased, legs inflammation decreased. Other remained.

Mid-SEP

JA began to have his appetite with less nauseous effect. Decreasement in skin itchiness, legs and arms inflammation. Other cancerous impact remained.

Late-SEP

JA had his appetite with slight decreasement in nauseous effect. Skin itchiness decreased up to hair-growing point, no legs and arms inflammation, less suffocation and lung crowded. Body remained immobile for a week with some phlegm cough.

Early-OCT

JA had his appetite. Slight nauseous effect and body inflammation. JA has constant phlegm cough, not as excessive as usual. Suffocation and crowded lung sensation reduced.

Mid-OCT

JA seemed healthy with no complain, except excessive phlegm cough

Late-OCT

JA had constant progress from the previous week

Early-NOV

JA had skin itchiness and phlegm cough with no other complain.

Mid-NOV

JA received improvement in MC/VER, Lymphocytes, Eosinophil number with excessive no-phlegm cough. Other indicated negative.

Late-NOV

JA complained about weakened body and bone achness. JA still showed excessive no-phlegm cough with a slight suffocation. No other negative indication.

Early-Dec

JA gained energy again, less bone achness. JA showed less excessive phlegm cough with no suffocation and no other negative indication.

Mid-Dec

JA had energy to go downstairs (3rd floor) with slight suffocation and three phlegm coughs per hour. No other negative indication.

Late-Dec

JA was able to eat, travel, and drive for one week straight without suffocation issue reported. JA had no-phlegm cough four to five every day with arms and legs slight inflammation and skin itchiness on head once a day. No other negative indication. 

Monthly Notes and Progress 2024

MONTHS

Early-JAN

JA had constant progress as previous week. With slight increasement in skin itchiness.

Mid-JAN

JA indicated crowded lung and suffocation sensation again with increasing phlegm cough. But JA had skin itchiness and inflammation reduced. No other negative indication.

Late-JAN

JA had less suffocation feeling with no crowded lung and phlegm cough. JA had normal three to five a day no-phlegm cough with reducement in skin itchiness. Body inflammation remained. No other negative indication.

Early-FEB

JA had constant progress from previous week.

Mid-FEB

JA had constant progress from previous week

Late-FEB

JA showed excessive no-phlegm cough with suffocation, body weakened, and nauseous. Skin itchiness reduced and body inflammation disappeared. Any cancerous impacts showed slightly.

Early-MAR

JA had constant progress from previous week, except skin itchiness disappeared and crowded lung increased.

Mid-MAR

JA had constant progress from previous week.

Late-MAR

JA had constant progress from previous week, except his body began gather energy. He could walk and did simple yoga freely.

Early-APR

JA had bone achness with body weakened. Other negative indications were reduced to a normal level.

Mid-APR

JA’s bone achness was healed progressively. JA could move his body again. Other negative indications were reduced to a normal level, except excessive no-phlegm cough

Late-APR

JA had abdominal problem, excessive nauseous, and eating disorder leading to weightloss and excessive no-phlegm cough with suffocation. No skin itchiness, inflammation, or crowded lung sensation.

Early-MAY

JA had increasement in abdominal problem, involving stomach size issue with nauseous and vomiting everytime eating or drinking. Cough decreased, along with other negative indication.

Mid-MAY

JA had constant negative progress from previous week, notably in stomach issue, nauseous, and body weakened.

Late-MAY

JA showed bone achness with blader issue and constant progress from previous week with no cough, inflammation, skin itchiness, crowded lung.

Early-JUN

JA had gained body energy and removed bone achness. JA began to have his appetite and reduced his nauseous. JA reported blade issue, such as excessive pee and sometimes hampered. No other negative indication.

Mid-JUN

JA had no excessive cough and suffocation with crowded lung sensation. JA showed weightloss with feet inflammation. JA had prostat widening issue with stomach size problem. No other negative indication.

Late-JUN

JA had normal cough three to five a day with no suffocation and body power gained. JA could sit on the living room and walked to the downstairs again. Feet inflammation reduced. No other negative indication, except blader and stomach.

Early-JUL

JA showed significant change positively. JA could move freely with slight feet inflammation due to blader issue. JA did not suffer excessive phlegm or no-phlegm cough nor suffocation. JA sometimes reported slight crowded lung. JA remained to have stomach size issue, however reduced.

Mid-JUL

JA’s stomach had significantly back to its normal size, however, might bloated again. JA remained to suffer blader issue with feet inflammation. JA did have no-phlegm cough but without suffocation or crowded lung. JA was free from immobility due to bone achness or weakened body. Other negative indications disappeared.

Late-JUL

JA’s progress remained still, except some positive improvements viz body energy, stomach issue, and crowded lung. JA could drive a car, walked downstair, and sat outside with less cough than before. JA still suffered from no-phlegm cough. No other negative indications.